NSS Program & Topics​

The IEEE Nuclear Science Symposium (NSS)

The IEEE Nuclear Science Symposium (NSS) brings together the very large and diverse international community of ionizing radiation detector scientists and engineers. We look forward to welcoming you in the beautiful city of Yokohama in 2025!

The NSS 2025 program incorporates the latest developments in detector technology and materials, new instrumentation techniques, their implementation in high energy and nuclear physics, astrophysics, accelerators, nuclear security, and many other applications in various types of radiation environments. The program will also include emerging fields and current hot topics in nuclear science instrumentation.

Interdisciplinary state-of-the-art developments will be included in the joint sessions with the MIC and RTSD. Special topic workshops will cover areas of specific interests and short courses will be offered on a variety of traditional and novel topics of interest to the NSS community.

NSS Topics

Authors are invited to submit papers describing their original, unpublished work on one of the topics below:

  • Analog & Digital Circuits
  • Detectors for Astrophysics and Space Applications
  • AI and Machine Learning for Radiation Detection
  • Computational Methods, Modeling and Data Analysis
  • DAQ, Trigger and Front End Electronics
  • Gaseous Detectors
  • Neutron and Gamma Ray Detectors
  • Nonproliferation, Homeland Security & Safeguards, Treaty Verification and Contraband Detection
  • Novel detectors (Dark Matter, Neutrinos, Double Beta Decay, Muon Imaging, etc.)
  • Nuclear and High Energy Physics
  • Nuclear Instrumentation and Measurement for Nuclear Fission, Nuclear Fusion and Dosimetry
  • Photodetectors
  • Radiation Damage Effects and Rad Hard Devices
  • Scintillation Materials
  • Scintillation Detectors
  • Semiconductor Detectors

NSS Plenary Sessions

Yoshie Otake

RIKEN Compact neutron systems for on-site use, RANS project

Hiroyuki Tanaka

Muography

Yutaka Matsuo

Generative AI and the Future of Scientific Discovery

Milind Vaman Diwan

The Science and Technology of Accelerator Based Neutrino Detectors

MIC Program & Topics

The IEEE Medical Imaging Conference (MIC)

The IEEE Medical Imaging Conference (MIC) is a leading international scientific meeting to discuss the latest physics, engineering, and mathematical innovations in medical imaging with a particular focus on applications of ionizing radiation.

Medical imaging in nuclear medicine and radiology as well as molecular imaging is a continuously growing field where technical advances in detectors, instrumentation, computational methods, and integrated systems pave the way towards advances in clinical detection, diagnosis, treatment, and monitoring as well as clinical research into the underlying mechanisms of disease and treatment. In recent years, there has been increased interest in applications of machine learning, AI, and other rapidly emerging areas of research, and innovations in these areas continue to play an increasing role in medical imaging.

MIC is an opportunity for students, post-doctoral fellows, and junior and senior researchers from around the world to come together to share their new ideas and results of innovations and scientific endeavors.

The scientific program of the MIC consists of oral and poster sessions, plenary sessions, and a student award session. Regular sessions will be complemented by Short Courses and specialized workshops covering timely topics in medical imaging and therapy.

MIC Topics

Authors are invited to submit papers describing their original, unpublished work on one of the topics below:

  • New radiation detector technologies for medical imaging
  • Simulation and modeling of medical imaging systems
  • Total-body, whole-body, and multi-modality clinical emission systems
  • High resolution imaging systems (organ-dedicated, small animal systems)
  • X-ray imaging systems (CT, spectral CT, photo-counting CT)
  • Tomographic reconstruction techniques
  • Quantitative imaging, image assessment and standardization
  • Signal and image processing
  • Kinetic modeling
  • Imaging and dosimetry in therapy (particle, radiopharmaceutical, surgery)
  • Emerging applications, new concepts

MIC Plenary Sessions

Ming-Kuei Jang

Development of Pharmaceuticals for Neurodegeneration with PET Imaging

Yukie Yoshii

Development of 64Cu-based radiotheranostics for cancer diagnosis and treatment

Chuck Melcher

Forty Years of LSO

RTSD Program & Topics

Room Temperature Semiconductor Detector Conference (RTSD)

The Room Temperature Semiconductor Detector Conference (RTSD) represents the largest forum of scientists and engineers developing compound semiconductor radiation detectors and imaging arrays operable at room temperature.

Room-temperature semiconductor radiation detectors are finding increasing applications in such diverse fields as medicine, homeland security, radiography, astrophysics and environmental monitoring. The objective of this conference is to provide a forum for discussion of the state of the art for room-temperature-operating detector technology based on compound semiconductors, including materials improvement, material and device characterizations, fabrication, electronic readout, system development and applications. To provide a comprehensive review, oral and poster presentations representing a broad spectrum of research and development activities emphasizing compound semiconductor detectors or imaging devices are sought.

RTSD Topics

  • Compound Semiconductor Materials for Radiation Detection
  • Organic and Perovskite Materials for Radiation Detection
  • Crystal Growth, Materials and Defect Characterization
  • Properties of Electrical Contacts and Device Fabrication Technology
  • Radiation Damage, Long-Term Stability and Environmental Effects
  • Pixel, Strip, Frisch-Grid and Discrete Semiconductor Detectors
  • Detector/ASIC Hybridization, Interconnects and Electronics
  • Scintillator/Semiconductor Array Hybrids
  • Compound Semiconductor Neutron Detectors
  • 3D Photon Tracking Detectors and Image Reconstruction Technology
  • Use of AI/ML tools for Analysis of Detector Signals and Decision Making
  • Spectrometer Systems for Homeland Security, Nuclear Inspections, Safeguards, Portal Monitoring, and Other Uses
  • Imaging Systems based on Compound Semiconductor Detectors for Medical, Astrophysics, Non-Destructive Testing, Cargo Monitoring, Environmental Monitoring and Other Uses

Workshops

Workshop 1: Current status and Future Prospects of Neutron Beam Facilities

Description

In recent years, many neutron beam facilities have been operating around the world, and the use of neutrons has led to a variety of scientific achievements. This workshop will provide a concise overview of reactor-based and accelerator-based neutron beam facilities, neutron instruments, future plans, and development work currently underway around the world.

Experts

Workshop 1.1: Digital SiPM and SPAD based sensors – technology roadmaps and applications

Description

With analog SiPMs now in use across-the-board, digital SiPMs and SPAD based devices see accelerated development activity with the potential of improving current photon counting systems and making them readily available. The main NSS program reports on technology performance and application use of actual available technologies. The goal of the workshop is to provide a place where upcoming/future technologies can be described by their developers, development roadmaps can be disclosed, and application niches or markets are aimed for. This is not the type of communication that you regularly see in the main program.

During this afternoon workshop, we will hear developers of digital SiPM and SPAD based devices (this is meant as inclusive as possible, from academic groups, institutes to commercial foundries) present their technology proposal and roadmaps aimed at applications in the realm of the NSS MIC RTSD conference. The goal is to keep present and future stakeholders informed and engaged in the development of these technologies. 

Contact

Developers and stakeholders are welcome to submit communication to us by email.

Co-organisers

Workshop 2: Scintillator-based photon counting CT detectors

Description

This workshop aims to bring together the researchers in our community who share an interest in the “old but new” approach of using scintillators in detectors for spectral, photon-counting x-ray computed tomography (PCD CT). Commercial PCD CT systems have recently become available and studies in various clinical disciplines are already showcasing their added value. This success has been enabled by decades of research on room-temperature semiconductor detectors (RTDS), such as CdTe, CZT, silicon, and GaAs. Nevertheless, systems based on such detectors are expensive and their spectral performance is still limited due to charge sharing. Several researchers around the world have recently realized that detectors based on modern, ultrafast scintillators and silicon photomultipliers (SiPM) may offer a cost-effective alternative, which inherently does not suffer from charge sharing. Such detectors could even open up the possibility of applying the time-of-flight principle in CT in future. This is a rapidly growing field of research, with more talks and posters on this topic during NSS/MIC/RTSD 2025 than years before.

We believe the time is right to initiate a forum to showcase on-going research activities by the pioneering groups in this emerging field, discuss the pertinent research challenges, and foster new collaborations. Whereas the research into this topic has been on basic levels until about 2024, we now start to see imaging studies using prototype scintillation detectors in table-top CT systems, as well as modelling studies that unravel the spectral and non-spectral performance characteristics for different CT imaging tasks.

We invite you to join the discussion on this exciting topic.

Experts

Tentative program

8:00 am – Welcome
8:10 am – General introduction, scintillators*, silicon photomultipliers*
9:30 am – Coffee break
10:00 am – Detector physics, table-top systems, system modeling, algorithms, performance assessment
12:00 pm – Discussion
1:00 pm – Adjourn

Workshop 3: Total-Body Kinetic Modeling Workshop

Description

This workshop is designed to serve as a forum for discussing the emerging field of total-body PET kinetic modeling and its future directions. There are currently over fifty total-body PET and long axial field-of-view PET scanners operating across four continents. This workshop is timely to discuss the growing need for effective handling of total-body data for dynamic imaging and kinetic modeling. Such advancements are essential for extracting physiologically significant information that traditional static imaging methods could not achieve. We plan to invite experts from various levels of experience, including both senior and junior researchers, to present an overview of the technical challenges, progress, and clinical applications in this field. The workshop will facilitate not only rich exchanges of ideas but also offer a hands-on exercise session. Participants will have the opportunity to work with real patient data from total-body dynamic PET scans. Importantly, this workshop is designed to complement the existing MIC program on kinetic modeling, providing invited talks and practical sessions without overlapping with current offerings.

Experts

Tentative program

12:10 pm – Collect lunch boxes
1:00 pm – Invited Talks
3:50 pm – Coffee Break
4:20 pm – Debate: Total-body parametric imaging
5:20 pm – Hands-on Exercises Session (primarily for student registrants)
7:00 pm – Dinner and Social

Workshop 4: Opportunities for Nuclear and Plasma for Energy and Society

Description

Following the success of the NPSS Climate Workshop at NSS-MIC 2024 in Tampa and the renewed global interest in nuclear energy, we are pleased to host a half-day workshop at the NSS-MIC 2025 in Yokohama. This session will explore the evolving role of nuclear and plasma science in addressing society’s urgent energy, environmental and medical challenges.
We will explore critical topics such as fusion energy and its long-term impact and public perceptioninnovative nuclear technologies beyond power generationsustainable applications in nuclear medicine, and redox nuclear batteries using depleted uranium. This workshop offers a unique forum for interdisciplinary dialogue among scientists and engineers committed to shaping a cleaner, more resilient future.

The Workshop will require registration but is free of charge for NSS-MIC-RTSD participants.

Joining the live session
This is an external workshop. Information on how to join the session can be found on the workshops website.

Experts

Organisers

Workshop 5: Ultra low dose PET

Description

Positron Emision Tomography (PET) tracks the biological uptake of mollecules of biological interest labelled with positron emitters such as 18F-FDG. The introduction of Long Axial Field of View (LAFOV) scanners supposed a change in paradigm in PET imaging with a much increased sensitivity (>10x) compared to standard PET counterparts. That allows for reduced times in acquisition and/or reduced injected activity while keeping image quality compatible with the clinical practice. Furthermore, Deep Learning (DL) methodologies can be leveraged to achieve even lower dose delivered to the patients without affecting the quality of the reconstructed images. Following the experiences of previous years (2022-2024), we proposed a workshop to encourage the development of new DL methods for high quality image generation from ultra low dose PET scans (<1 mSv). As in previous editions we will released an open access dataset comprising data from two LAFOV clinical scanners (Biograph Vision Quadra by Siemens Healthineers and uExplorer by United Imaging). Last year, the dataset comprised more than 380 18F-FDG images for Biograph Vision Quadra and more than 1000 for uExplorer. In all cases, the full dose (standard clinical protocol) reconstructed images are provided together with the reconstructed images for the same patients with dose redutions of 4, 10, 20, 50 and 100. This year, the dataset corresponding to the Biograph Vision Quadra will be increased to achieve ~500 cases. Participants will be invited to download the dataset and develop DL algorithms for low dose PET enhancement and submit them until 1 month before the conference. Algorithms submitted will be tested and analysed following objective metrics to determine the best performance ones. The worshop will be separated the workshop in two parts:

Part 1: summary of the last updates in the scientific community for low dose and ultra low dose PET imaging with invited speakers (expected 4 speakers) followed by a discussion in a QA form with all the speakers.

Part 2: announcement of the winners of the challenge and selected presentations of the best algorithms.

Organizers

Satellite workshop: Imagine Nuclear Medicine Instrumentation in 2035

Description

It is no exaggeration to say that the innovation in nuclear medicine instrumentation has been born at IEEE NSS-MIC-RTSD. Following PET/CT, time-of-flight, PET/MR, SiPM-based PET, CZT-based SPECT and total-body PET, what other amazing devices will be in practical use in 10 years?  Bridging the research results in IEEE NSS-MIC-RTSD to clinical nuclear medicine, the Japanese Society of Nuclear Medicine (JSNM) and the Japanese Society of Nuclear Medicine Technology (JSNMT) annual meetings will be held in the ancient city of Kyoto the week after the IEEE NSS-MIC-RTSD is held in Yokohama. Therefore, we plan a workshop, jointly held with JSNM and JSNMT, to discuss the future of nuclear medicine instrumentation and software from the perspectives of both physics and medicine. How will next-generation equipment change nuclear medicine clinical practice? Let’s relax and immerse ourselves in history in the heart of Kyoto and talk passionately about nuclear medicine 10 years from now.

Experts

Go Akamatsu, Ph. D., QST
Simon Cherry, Ph. D., UC Davis
Kimiteru Ito, M.D., Ph. D., National Cancer Center Hospital
Jae Sung Lee, Ph. D., Seoul National University Hospital
Craig Levin, Ph. D. Stanford University
Miwako Takahashi, M.D., Ph. D., QST
Taiga Yamaya, Ph. D., QST

Co-hosts

IEEE NSS-MIC-RTSD
Japanese Society of Nuclear Medicine (JSNM)
Japanese Society of Nuclear Medicine Technology (JSNMT)
Study Group on Radiation Science and Its Application

Call for abstracts [Closed]

Registration

A separate registration for JSNM-JSNMT is required. One-day registration is also available for this workshop, but full registration for IEEE2025 (including student discount) is required. Details will be announced later. Please check the JSNM registration page and select “One-Day Registration (Nov. 13) for IEEE2025 Participants: 7,000 JPY”.

Short Courses

Instructors:

  • James Ghawaly, Louisiana State University

Course Description

This short course introduces deep learning artificial intelligence (AI) and its application to the detection of radioactive sources amongst a noisy background. Designed for graduate students and professionals in nuclear engineering, physics, computer science, and related STEM fields, the curriculum will cover fundamental AI concepts, deep learning, and foundation models. We will then introduce and discuss recent works in the application of these technologies to radioactive source detection. We will also perform a hands-on exercise using a public dataset and published AI models to enable participates to gain practical insights into the process of training and evaluating AI systems for this field. By the end of this course, attendees will possess the knowledge and skills required for continuing education around AI integration in radiation detection systems. Participants are encouraged to bring a laptop with a working installation of Python version 3.10+ and virtualenv for the hands-on exercise.

Course Outline

  • Introduce to Machine Learning and Artificial Intelligence
  • Introduce to Deep Learning
  • Introduction to Radioactive Source Detection
  • Discussion of Published Works in Deep Learning + Radiation Detection
  • Hands-on Exercises Using Public Data and Models

Prerequisites

Basic understanding of radiation detection and transport, differential, integral, and multivariate calculus, linear algebra, and ability to write basic programs in the Python programming language. Participants are encouraged to bring a laptop with a working installation of Python version 3.10+ and virtualenv for the hands-on exercise.

Instructors’ Biographies

Dr. James Ghawaly Jr. is an Assistant Professor of Computer Science & Engineering at Louisiana State University (LSU), where he researches modern and emerging machine learning techniques, with applications to national security. He also holds joint appointments with the LSU Center for Computation and Technology (CCT) and the LSU Office of Academic Affairs (OAA). Prior to LSU, he was a staff research data scientist at Oak Ridge National Laboratory (ORNL). In the past 5 years, he has led over $2m in research efforts to develop deep learning and neuromorphic computing approaches for national security challenges, sponsored by DOE NNSA, DHS CWMD, DTRA, and other federal government agencies. Dr. Ghawaly has developed deep learning approaches to signature detection in low signal-to-noise ratio sensor data streams, multimodal data fusion algorithms (imagery, LiDAR, text, time series sensor data) for object detection and characterization, LLMs for cybersecurity applications, and multimodal contrastive learning approaches for object similarity detection. At LSU, he teaches a courses on large language models (LLMs), deep learning, and foundation models for undergraduate upperclassman and graduate students.

Instructors:

  • David Wehe, University of Michigan, USA
  • Paul Schotanus, SCIONIX, NL
  • Chris Wahl, H3D, USA

Course Description

This half-day course provides an introduction to basic concepts that underlie the operation of all major types of instruments used in the detection and spectroscopy of charged particles, gamma rays, and other forms of ionizing radiation. Emphasis is on understanding the fundamental processes that govern the operation of radiation detectors. This ”gateway” course is intended to serve as an on-ramp for attendees who  would benefit from enriching their knowledge prior to other short courses and the conference technical sessions. A complete set of course notes is provided to registrants, and a recent copy of Radiation Detection and Measurement by G. F. Knoll is highly recommended.

Course Outline

I. Fundamental Concepts in Ionizing Radiation Detection
II. Scintillation Detectors
III. Modern Semiconductor Detectors

Instructors’ Biographies

DAVID WEHE is Professor of Nuclear Engineering and Radiological Sciences at the University of Michigan. He worked at the Oak Ridge National Laboratory as a Wigner Fellow and served as Director of the Michigan Phoenix Memorial Project, which included the 2-MW Ford Nuclear Reactor. His teaching and research have focused on applied radiation measurements, as an editor for Nuclear Instruments and Methods in Physics Research and general chair of the SORMA international conference series.

PAUL SCHOTANUS started his work on scintillation materials at the Delft University of Technology researching the luminescence properties of barium fluoride applied to positron emission tomography. Later he worked at universities (University Utrecht, TU Eindhoven) on the application of scintillation materials in various physics projects. His interest is the design and use of dedicated scintillation sensors in science, industry, medicine, and security. His research focuses on the optimum use of scintillation crystals and he is the managing director of SCIONIX Holland.

CHRIS WAHL is the Director of Operations and Research and Development Engineer at H3D, Inc. He earned his Ph.D. from the University of Michigan with a focus on pixelated CZT detectors for imaging applications and completed a postdoc in the Physics Department at Yale University. He is deeply involved in H3D’s mission to change the paradigm of radiation detection through the development of room-temperature semiconductor detectors for power, waste, security, and medical applications.

Instructors:

  • Paul O’Connor, Brookhaven Lab
  • Raffaele Giordano, University of Naples
  • Kenji Shimazoe, University of Tokyo

Course Description

This one-day course is intended to introduce physicists and detector specialists to the fundamentals of integrated circuits (IC), front end design, and radiation-hardened design.

The course provides an overview of analog design methodologies and semiconductor devices and then delves into the details of implementing practical circuits in modern CMOS technology. In the second part of the course, the participants will learn state-of-the-art design techniques to implement radiation-hardened reconfigurable digital circuits in the radiation detection readout.

Course Outline

Analog front-end design (O’Connor)

  • Brief introduction to design methodology (CAD tools and foundry access for research-scale projects)
  • Analog circuit design
  • Basic architectures with elementary amplifiers
  • Building blocks for the analog channel: charge-sensitive and pulse-shaping amplifiers, baseline stabilizers, peak detectors, track/hold, multiplexers, output stages
  • Feature extraction: event occurrence, position, time, energy
  • Overview of analog-to-digital and time-to-digital converters

Silicon photomultiplier readout electronics (Kenji Shimazoe)

  • Brief introduction on silicon photomultipliers
  • Medical applications and requirements for SiPM systems
  • Readout electronics architecture for SiPMs
  • Fast timing electronics
  • Data acquisition with digital electronics (FPGA)
  • Application examples in medical imaging

Radiation-tolerant design (Raffaele Giordano)

  • Basics of radiation effects in microelectronics
  • Introduction to radiation hardening by design in digital circuits
  • Techniques for real-time self-repair in reconfigurable ICs

Instructors’ Biographies

Paul O’Connor is senior scientist and Division Head in Instrumentation at Brookhaven National Laboratory. He attended Brown University, earning a master’s degree in electrical engineering in 1977 and a Ph.D. in physics in 1980. He joined AT&T Bell Laboratories as a member of the technical staff in 1980 and arrived at Brookhaven Lab in 1990. His research focus is low-noise readout electronics for radiation detectors, signal processing, and detector systems. He is author on more than 150 publications and has seven patents for microelectronic and detector technologies..

Rafaelle Giordano is associate professor in the Department of Physics at the University of Naples Federico II (Unina), Italy. He received the master’s and Ph.D. degrees in physics from the same institution in 2007 and 2010, respectively. As a postdoctoral researcher and assistant professor he has been involved in experiments at CERN and at the Japan High Energy Accelerator Research Organization, KEK. Since 2016, he is a faculty member at Unina where he leads R&D projects on novel instrumentation for High-Energy Physics. He is an author of more than 390 scientific papers and holds two international patents for digital oscillators and radiation hardening techniques.

Kenji Shimazoe is associate professor in the Department of Nuclear Engineering and Management, Department of Bioengineering at the University of Tokyo. His research focuses on quantum measurement and sensing technology directed towards improving the performance of medical diagnostic instruments and developing new functional medical imaging modalities.

Instructors:

  • Scott S. Hsieh, Mayo Clinic
  • Rafael Ballabriga, CERN

Course Description

This course provides a comprehensive overview of photon counting CT imaging from basic principles to current state of the art. This encompasses basic design and architecture, comparison to existing detectors, circuit design, and the algorithms used for postprocessing and CT image formation. The course is designed for engineers and physicists who wish to gain or deepen the knowledge on this emerging field of research. 

Course Outline

  • Detector architecture and its main components (sensor, ASIC)
  • Advantages of photon counting compared to energy integrating
  • Sensor materials being investigated today
  • Physics and non-idealities of common sensor materials
  • ASIC design and key tradeoffs 
  • Review of existing ASICs
  • Algorithms for basis material decomposition 
  • Relationship of detector to other CT scanner components
  • Current and future clinical applications
  • Imaging figures of merit

Prerequisites for this course: Basic understanding of CT physics and mathematics.

Instructors’ Biographies

Scott S. Hsieh is an Assistant Professor of Radiology at Mayo Clinic Rochester. Dr. Hsieh’s work is primarily in the design of better x-ray detectors and CT systems, and spans the range from basic physics to clinical applications. His past contributions include improved on-chip corrections for photon counting detector non-idealities and dynamic bowtie filters for reducing radiation exposure on CT scanners. He is a past recipient of an NIH/NIBIB Trailblazer Award on x-ray system design and is supported by the NIBIB on other projects related to improved detector technologies.

Rafael Ballabriga is a graduate of the Ramon Llull University in Barcelona (BSc 2000, MSc 2002). In 2004, he joined CERN microelectronics group, Geneva (Switzerland), in the framework of the CERN Doctoral Student Program to work in the design and characterization of hybrid pixel detectors for the Medipix International Collaborations. He defended his PhD thesis entitled “The Design and Implementation in 0.13um CMOS of an Algorithm Permitting Spectroscopic Imaging with High Spatial Resolution for Hybrid Pixel Detectors” in 2009 for which he received the best thesis award of the Ramon Llull university doctoral programme 2009-2010. He has experience on the design of Monolithic Active Pixel Sensors for High Energy Physics and on ASICs for the readout of fast detectors with intrinsic amplification (PMTs, SiPMs, MCPs)

Rafael Ballabriga received the IEEE NPSS Best Student Paper Award in 2006 and the IEEE Nuclear and Plasma Sciences Society Radiation Instrumentation Early Career Award in 2013.

Rafael Ballabriga has coached younger designers in the design of front-ends in CMOS technologies. Holds three patents and has authored or co-authored more than 100 peer-reviewed journal publications.

Instructors:

  • Joyita Dutta, University of Massachusetts Amherst
  • Arman Rahmim, University of British Columbia
  • Jinyi Qi, University of California
  • Quanzheng Li, Massachusetts General Hospital

Course Description

This course delves into the cutting-edge techniques of medical imaging reconstruction and processing, with a focus on molecular imaging modalities, especially PET. Participants will explore how Artificial Intelligence (AI) revolutionizes reconstruction and processing tasks, enhancing image quality, diagnostic accuracy, and clinical utility. Through a combination of theoretical knowledge, practical demonstrations, and hands-on exercises, participants will gain proficiency in leveraging AI for advanced image reconstruction and processing in molecular imaging.

Course Outline

  • Overview of medical imaging modalities, image reconstruction, and processing Basics and core principles of AI and machine learning
  • AI-Based Image Reconstruction Techniques
  • Quantitative Corrections
  • AI-Based Image Enhancement
  • Clinical Applications and Emerging
  • Directions
  • Hands-On Workshop

Prerequisites

  • Linear algebra basics
  • Probability and statistics basics
  • Python programming basics

Instructors’ Biographies

Dr. Joyita Dutta is Professor with tenure in the Department of Biomedical Engineering at the University of Massachusetts Amherst. She received her BTech (Honors) from the Indian Institute of Technology (IIT) Kharagpur and MS and PhD from the University of Southern California. She directs the Biomedical Imaging and Data Science Laboratory (BIDSLab) at UMass Amherst, which develops signal processing and artificial intelligence (AI) techniques for image, graph, and time-series datasets. Her scientific contributions include the development of a broad range of tools for medical image enhancement and reconstruction with a focus on multimodality information integration. Her current research interests include developing AI approaches for the diagnosis and prognosis of Alzheimer’s disease. Dr. Dutta was the recipient of the 2016 SNMMI Tracy Lynn Faber Memorial Award and the 2016 IEEE Bruce Hasegawa Young Investigator Medical Imaging Science Award. Dr. Dutta has served as a member of the SNMMI AI Task Force and the Program Chair for the 2022 IEEE Medical Imaging Conference in Milan, Italy. She is the Immediate Past President of the SNMMI Physics, Instrumentation and Data Sciences Council (PIDSC). Her trainees at BIDSLab have been awarded prestigious extramural training grants from the SNMMI, IEEE, APS, and AAUW.

Dr. Arman Rahmim is Professor of Radiology, Physics, and Biomedical Engineering at the University of British Columbia (UBC) and a Distinguished Scientist and Provincial Medical Imaging Physicist at BC Cancer. He earned his MSc in condensed matter physics and PhD in medical imaging physics at UBC. After completing his PhD, he joined Johns Hopkins University (JHU) to lead the high-resolution brain PET imaging physics program and conduct research in Radiology and Electrical Engineering. In 2018, he returned to Vancouver to continue his research in molecular imaging and therapy. Dr. Rahmim has published a book, over 300 journal articles, and delivered more than 200 invited lectures worldwide. He has been a principal or co-investigator on various grants for quantitative imaging and personalized therapies. He received the Young Scientist Award from the AAPM in 2016, the Presidential Distinguished Service Award from SNMMI in 2022, and the Edward J. Hoffman Award from SNMMI in 2025. He has served as Vice President (2017-18) and President (2018-19) of the SNMMI’s Physics, Instrumentation and Data Sciences Council (PIDSC), and has chaired the SNMMI Artificial Intelligence (AI) Task Force (2020-2024) and the SNMMI Dosimetry-AI working group (2022-).

Dr. Jinyi Qi is Professor in the Department of Biomedical Engineering at the University of California, Davis, where he leads a research laboratory that develops advanced signal and image processing techniques for molecular imaging, with a particular focus on statistically based image reconstruction methods for emission tomography. He received his B.S. in Electrical Engineering from Tsinghua University, Beijing, and his M.S. and Ph.D. degrees in Electrical Engineering from the University of Southern California. Dr. Qi is a Fellow of the American Institute for Medical and Biological Engineering (AIMBE) and a Fellow of the IEEE. He is the recipient of the IEEE Nuclear and Medical Imaging Sciences (NMIS) Young Investigator Medical Image Science Award (2001), the IEEE Nuclear and Plasma Sciences Society (NPSS) Early Achievement Award (2009), and the Edward J. Hoffman Award from the Society of Nuclear Medicine and Molecular Imaging (SNMMI) (2024). He currently serves as an Associate Editor for IEEE Transactions on Medical Imaging and IEEE Transactions on Radiation and Plasma Medical Sciences.

Dr. Quanzheng (Q) Li is Associate Professor of Radiology at the Massachusetts General Hospital, Harvard Medical School. He is also the Director of the Center for Advanced Medical Computing and Analysis, a Core faculty of the Gordon Center for Medical Imaging, and the Scientific Director of the MGH/BWH Center for Clinical Data Science, Massachusetts General Hospital, Harvard Medical School. He did his postdoctoral training at USC, from 2006 to 2007, and was a Research Assistant Professor, from 2008 to 2010. In 2011, he joined the Radiology Department, at Massachusetts General Hospital. He is a recipient of the 2015 IEEE Nuclear and Plasma Sciences Society (NPSS) Early Achievement Award. His research interests include image reconstruction and analysis in PET, SPECT, CT, and MRI, and data science in health and medicine.

Our course will also include contributions from:
(i) Dr. Fereshteh Yousefirizi, Staff Scientist from BC Cancer Research Institute, Vancouver, whose main research interests include developing advanced machine and deep learning frameworks to enhance nuclear medicine image processing, quantification and outcome prediction.
(ii) Ziyuan Zhou, PhD Student from the Department of Biomedical Engineering, University of Massachusetts Amherst, whose research interests include developing AI-based PET image enhancement.
(iii) Maziar Sabouri, PhD Student from the Department of Physics & Astronomy, University of British Columbia, Vancouver, whose research interests include AI-based image processing applied to nuclear medicine imaging.

Instructors:

  • Wesley E. Bolch, University of Florida
  • Robert Hobbs, Johns Hopkins University
  • Yong Du, Johns Hopkins University

Course Description

Radiopharmaceutical therapy (RPT) is a targeted approach for cancer treatment. By combining a radioactive isotope with a targeting molecule, RPT selectively binds to diseased cells, delivering beta particles or alpha particles directly to them while minimizing damage to healthy tissues. It has been successfully applied to treat various cancers, including neuroendocrine tumors (Lutetium-177 DOTATATE), prostate cancer (Lutetium-177 PSMA), bone metastases (Radium-223), and thyroid cancer (Iodine-131). RPT offers advantages such as precise targeting, systemic reach, and personalized dosing through dosimetry-based approaches. This course will provide a comprehensive overview of radiopharmaceutical therapy, dosimetry principles, and clinical applications.

Course Outline

  • Overview of RPT, key principles, and clinical applications
  • Design and Mechanism of Action
  • Alpha emitter RPT
  • Fundamentals of dosimetry and personalized treatment planning
  • Imaging based dosimetry for RPT
  • Voxel-Based and Organ-Based Dosimetry
  • Microdosimetry
  • Clinical Applications of RPT and Case studies
  • Radiobiology and Radiation Safety in RPT
  • Challenges and Innovations in RPT

Prerequisites

  • Basic understanding of radiation physics and biology
  • Basic understanding of nuclear medicine imaging

Instructors’ Biographies

Wesley E. Bolch is Distinguished Professor of Biomedical Engineering and Medical Physics in the J. Crayton Pruitt Family Department of Biomedical Engineering at the University of Florida (UF). He serves as Director of ALRADS – the Advanced Laboratory for Radiation Dosimetry Studies at UF.  Dr. Bolch earned his BSE degree in environmental engineering in 1984, his ME and PhD degrees in radiological physics in 1986 and 1998, respectively, from the University of Florida.  He has been certified by the American Board of Health Physics since 1994 and licensed in Radiological Health Engineering by the Texas Board of Professional Engineers since 1992.  In 2011, Dr. Bolch was elected Fellow of both the Health Physics Society (HPS) and the American Association of Physicists in Medicine (AAPM). In 2020, he was inducted as Fellow of the American Institute for Medical and Biological Engineering. He has been a member of the Society of Nuclear Medicine’s Medical Internal Radiation Dose (MIRD) Committee since 1993, a member of the National Council on Radiation Protection and Measurements (NCRP) since 2005 and served on Committee 2 of the International Commission on Radiological Protection (ICRP) from 2005 to 2011.  He has served as a member of US delegation of the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) since 2015. Within the latter, he serves as Lead Coordinating Writer for the Expert Group on Second Primary Cancers following Radiotherapy. He has published over 290 peer-reviewed journal articles, co-authored/edited 27 books/book chapters, and served as author on two AAPM Report, three MIRD Monographs, three NCRP Reports, twelve ICRP Publications, one ICRU Report. Dr. Bolch has managed a broad research program including (1) NIH and DOE funded projects to construct high-resolution models of the skeleton to support dose-response studies in radionuclide therapy and radiation epidemiology, (2) NIH funded projects to develop scalable NURBS-based and voxel-based computational phantoms of adult and pediatric patients and associated software for organ dose assessment in nuclear medicine, computed tomography, interventional fluoroscopy, and radiotherapy, (3) private company funded projects to develop stereotactic kilovoltage x-ray treatments for age-related macular degeneration and glaucoma, and (4) CDC, DoD, and NIH funded projects in stochastic modeling of worker inhalation and gamma-ray exposures following radiological accidents and potential terrorist events. He is the recipient of the 2014 Distinguish Scientific Achievement Award by the Health Physics Society acknowledging outstanding contributions to the science and technology of radiation safety.

Robert Hobbs is an Associate Professor and ABR- certified Medical Physicist in the Department of Radiation Oncology as well as Associate Professor in the Department of Radiology in the radioimmunotherapy and dosimetry lab. He has a Ph. D. in experimental high energy physics with extensive experience in code development, Monte Carlo modeling and simulation, pattern recognition, and data analysis. Since his conversion to nuclear medicine and medical physics, Dr. Hobbs has applied these skills to 3-D dosimetry and modeling and absorbed-dose based methodologies for radiopharmaceutical therapy. Specifically, Dr. Hobbs has developed methodologies for safe and effective combination therapies involving different radiopharmaceuticals or in tandem with external beam radiation. His major work has been to develop a small scale (sub-organ) dosimetric methodology, known as Macro2micro (M2m) for targeted alpha-particle radiopharmaceutical therapy specific to the short range and high LET of alpha-emitters, which combines geometrical modeling using patient-specific anatomical and pharmacokinetic data to supplement the available data from the standard nuclear medicine images. The methodology has been promoted by the ICRU, the MIRD Committee, and the newly formed RPT-TEC Committee, intra alia. This work has led to several NIH-funded R01s and is a major component of the recently-funded alpha-particle dosimetry P01. Similarly, his proposal standardized Relative Biological Effect (sRBEX) for relating alpha dosimetry to other radiation modalities has recently been adopted by the ICRU in Report 96, of which he was a contributing author, and translates alpha-emitter absorbed dose to the standardized low-LET absorbed dose EQDX. Consequently Dr. Hobbs is recognized as a world-leading expert and authority in a-particle and small scale dosimetry. Dr. Hobbs has served as an elected member of the MIRD (Medical Internal Radiation Dose) Committee, he is the chairman of the AAPM (American Association of Physicists in Medicine) Radiopharmaceutical Therapy sub-Committee, and serves on a number of committees and task groups that further the development, use and education of radiopharmaceutical therapy and dosimetry at AAPM, often in collaboration with other sister Medical physics organizations, such as the European Federation of Organizations of Medical Physicists (EFOMP) or the Society of Nuclear Medicine (SNMMMI). Dr. Hobbs also has served on Committees for a wide range of national and international organizations, including the International Atomic Energy Agency (IAEA), American Society of Radiation Oncology (ASTRO), National Cancer institute (NCI) and National Clinical Trials Network (NCTN). He is the 2025 recipient of the prestigious MIRD SNMMI Loevinger-Berman award for outstanding contribution to the field of Nuclear Medicine Dosimetry.

Yong Du is an Associate Professor in the Johns Hopkins University Department of Radiology and Radiological Science. His areas of expertise are SPECT and PET imaging physics, image reconstruction, photon transport simulation and modeling, quantitative image biomarker and data analysis, tracer kinetic modeling, and radiopharmaceutical therapy dosimetry. He applies these to solve medical problems in cardiology, oncology, and neurology. He is also experienced in the design and optimization of imaging protocols for animal studies and various clinical trials. He has developed and contributed to the development of several quantitative reconstruction methods for SPECT and radiopharmaceutical therapy dosimetry.

Instructors:

  • Marc Kachelrieß, German Cancer Research Center (DKFZ)
  • J. Webster Stayman, Johns Hopkins University

Course Description

Algorithms (classical and data-driven ones) are playing an increasingly important role in both the process of image formation in medical imaging systems as well as the downstream processing of those images for specific clinical tasks. Often such development is first performed in idealized simulations that do not always emulate all of the physically realistic elements. A plethora of effects including unknowns in calibrations, drift in calibration values, and “black box” processing by manufacturers can make it difficult to move from the idealized simulation scenario to real data. Thus, performance in simulation may not translate to real systems. This applies to both “testbench” scenarios where a developer has access to raw data, but also to clinical data from commercial systems where hidden preprocessing steps may already be integrated into the data. In this course, various strategies are discussed to integrate realistic x-ray and detector physics (for energy-integrating and for photon-counting detectors) into simulation studies, how to calibrate and translate those methods to physically acquired data, as well as methods for dealing with difficult-to-model physical effects or hidden processing.

Course Outline

  • Building a realistic x-ray physics model (testbench and clinical systems)
  • Unknowns and variability within an x-ray detection model
  • Classic techniques for calibration of unknowns
  • Advanced methods/Deep-learning-based calibration approaches
  • Adapting data processing algorithms to accommodate unknowns
  •  

Prerequisites

  • Basic understanding of x-ray physics and mathematics.

Instructors’ Biographies

Marc Kachelrieß is Professor of X-Ray Imaging and CT at the German Cancer Research Center (DKFZ). He received his PhD from the Institute of Medical Physics in 1998 under the guidance of Dr. Willi A. Kalender. During this time, he developed reconstruction algorithms to reduce metal artifacts in x-ray CT and he introduced a new method that allows the generation of motion-free images of the human heart using standard CT data. In 2005 he was appointed Professor of Medical Imaging at the Friedrich-Alexander-University Erlangen-Nürnberg, Germany and in 2011 he moved to the German Cancer Research Center (DKFZ), Heidelberg, Germany, as Professor and Chair of the Division of X-Ray Imaging and Computed Tomography. His current research covers image reconstruction of CT data, artifact reduction methods, dose reduction techniques, and sophisticated calibration techniques. Marc Kachelrieß is author or co-author of more than 150 peer-reviewed publications and more than 200 conference proceedings, and he is the organizer of several conferences and workshops in the field of tomographic and high performance imaging.

Webster Staymanis an Associate Professor of Biomedical Engineering at Johns Hopkins University. Dr. Stayman received his Electrical Engineering from the University of Michigan in Ann Arbor in 2003 and has been researching medical imaging systems for over 25 years. He has over 100 peer-reviewed journal publications and over 200 conference proceedings on topics spanning areas including image reconstruction and analysis methods for tomography; novel imaging system development including fluence-field modulated CT, point-of-care CT, and spectral CT; as well as research into physics-informed deep learning approaches. Dr. Stayman continues to promote investigation, translation, and education for novel imaging techniques that combine rigorous physics-based models with advanced data collection and processing schemes.

Please note that, unfortunately, virtual presentations may also occur due to travel restrictions that could possibly affect an instructor at short notice!

Special Events

Mentoring Event

Description

Mentoring program returning this year!

In the context of our Young Professionals activities we are offering a program providing coaching/ mentoring sessions again. Experienced members of the IEEE NPSS community, academics and industry professionals will welcome you to answer questions for 15 minutes, share their experience, and discuss your career goals. Please join us and take advantage of this unique opportunity to interact with experts in the field and get inspired! 

This year we will have a separate room (Exact location to be announced), where we may meet 1:1 or in small groups depending on the mentors and mentees! No sign up required, this will take place every lunch break.

Women in Engineering (WIE)

Description

We are delighted to announce the IEEE NPSS WIE Annual Event at the IEEE NSS MIC RTSD in Yokohama!

You are all invited to join us for our three-part event. We will welcome Pr. Kaoru SUMI, from the Future University Hakodate and WIE Coordinator of the IEEE Japan Council. She will present her research on Affective Computing and Human Interactions with technological agents. This will be followed by an interactive panel discussing challenges faced by women in academia and industrial research in Asian countries. The event will conclude with a networking event with drinks and small bites.

Please book your ticket during the registration to guarantee your participation and meal in this event. Other attendees are welcome to join us during the event but will not have access to the food and drinks. 

We are looking forward to welcoming you!

IEEE WIE Event Schedule

11:00 am – Welcome remarks
11:15 am – Presentation by Pr. SUMI
11:55 am – Panel
12:45 pm – Networking
1:30 pm – End of event

Organizer

NSS/RISC-MIC/NMISC FORUM for Next-Generation Professionals

Description

This RISC/NMISC forum intends to be an initiative to target the Next-Generation of volunteers by identifying and implementing means for increasing the opportunities for representation of students, middle career as well as underrepresented groups to be involved of the RISC and NMISC conference and events organization like: abstracts reviewers, session chairs, plenary speakers, organizing committee members, nomination for technical awards and RISC and NMISC elected positions. 

This forum will encourage broadly identifying and targeting the next generation of IEEE, NPSS, RITC leadership, seeking of opportunities to engage new young talents and motivated professionals at very early stages of their career.

The program will include:

  • Introduction by the RISC and NMISC leadership and committee members with supportive presence  of experienced NPSS members
  • Questions and feedback from the floor (some could be already prepared and communicated before this forum)

Who can attend? This forum is open to any NSS/MIC/RTSD attendee interested to participate in organization of NPSS-sponsored events such as this conference. A little ‘get together’ will be provided (food and drink). Space is limited to 40 participants. Registration is needed (first come, first served).

Organizer

GATE User Meeting

Description

The GATE toolkit has been in the research landscape for almost 20 years. This open-source software is designed to help researchers and engineers to perform a large range of Monte Carlo simulations in the medical physics field: PET, SPECT, Compton Camera, CT, CBCT (Cone-Beam CT) and radiation therapies.
The most recent release of the Monte Carlo simulation platform GATE (version 10) became available in November 2024. This version introduces a Python-based user interface, allowing users to integrate simulations with data analysis while reaching unprecedented levels of complexity through a programming language that is both simple and efficient, and now widely adopted across the research community.
Thus far, we have successfully re-implemented the majority of functionalities previously available in earlier versions of GATE for simulations in medical physics applications and are continuously extending the platform through the integration of new capabilities.
We encourage our community of users to participate in our annual workshop, the objectives will be to better understand the latest innovative applications in the field of imaging, to identify certain limits and to propose solutions adapted to the improvement of simulation practices.

Chairs
Olga Kochebina, BioMaps laboratory, CEA, University Paris-Saclay, France.
Emilie Rocali, Biomedical Engineering, UC Davis, USA.
Panagiotis Papadimitroulas, University of Thessaly, Greece.

Organizer

STIR Users' & Developers’ Meeting

Description

STIR is Open Source software for use in tomographic imaging. Its aim is to provide a Multi-Platform Object-Oriented framework for all data manipulations in tomographic imaging. The emphasis is on image reconstruction in emission tomography (PET and SPECT). This year is the 25th anniversary of STIR, and for this occasion we are organising a special edition of the STIR Users’ & Developers’ Meeting. This year there will be no abstract submission, instead we provide the following link to a short survey (https://www.surveymonkey.com/r/9HLJY7W) where attendees will have the possibility to choose a topic of their interest. Attendees will be sorted in groups based on the survey and will participate in a selected demo and discussion.

The event will include dinner. If interested in presenting contact the chairs before the 1st of September.

For up-to-date information please always check STIR website: 

Chairs

Technical Tours

Fukushima Daiichi Nuclear Power Plant Tour

Bus leaves from JR Tomioka station (Tomioka, Fukushima).

Tentative Schedule

Highlighted points must be arranged by yourself!

7:22 am – Leave JR Yokohama Station for Shinagawa
7:49 am – JR Tokyo Station: Change to Hitachi #3 express for Sendai
10:58 am – Arrive at JR Tomioka Station
11:20 am – Bus departs from JR Tomioka Station
11:30 am-3:20 pm – Guided tour of Fukushima Daiichi
3:30 pm – Bus departs for JR Tomioka Station
3:46 pm – JR Tomioka Station: Hitachi #22 express for Shinagawa
6:43 pm – Arrive at JR Tokyo Station
7:14 pm – Arrive at JR Yokohama Station

It is well known that the Fukushima Daiichi Nuclear Power Plant was attacked by Tsunami on March 11, 2011. All the electricity was lost and then the cooling systems were not functional later. Three of seven reactors were severely damaged by hydrogen explosions; thus, radioactivity confinement functions were all lost. It was almost 15 years ago, however, still this area suffers from a lot of problems. TEPCO has worked on the site recovery and they made great efforts to stabilize the facilities and made even external building outside. Now they started fuel-debris recovery and it requires very profound knowledge and wisdom of experts. There are still many issues to be discussed, however, it would be useful for you to see the reality of such a very big and important project of the decommissioning of the damaged reactor. The passport control in advance is required. Participants are supposed to come to the exit of the JR Tomioka station at 11:00 on November 10 by purchasing a train ticket to the JR Tomioka station. Then we will take you to the NPP by bus. Small lunch box will be supplied.

KEK Tour: Visit to High Energy Accelerator Research Organization

Schedule (updated November 7)

08:50 am – Meeting at Pacifico Yokohama North 1F entrance area
09:00 am – Bus departs from Pacifico Yokohama North
12:00 pm – Arrival at KEK & Lunch
1:00 pm-4:30pm – Tour of KEK Tsukuba campus
6:30 pm – Bus arrival at Pacifico Yokohama North

We organized a tour of the High Energy Accelerator Research Organization (KEK), where the world’s highest luminosity electron-positron collider experiment, Belle II, is running, and many other accelerator-related scientific activities are ongoing. More details about KEK can be found here.

Bus transportation from Pacifico Yokohama to KEK, which takes approximately two hours and lunch box are included in the participation fee.

QST Tour: PET Development Laboratory and Carbon-Ion Therapy Facility

Schedule (updated November 7)

12:00 pm – Meeting at Pacifico Yokohama North 1F entrance area
12:30 pm – Bus departs from Pacifico Yokohama North
2:00 pm-5:00 pm – Guided tour of QST
5:00 pm – Bus departs QST for return trip
5:10 pm – Drop-off at Chiba Station (only for participants traveling to Narita Airport)
6:10 pm – Bus arrives at Pacifico Yokohama North

We organized a tour of the National Institutes for Quantum Science and Technology (QST), formerly known as the National Institute of Radiological Sciences (NIRS).

It holds the world record for the highest number of cancer patients treated with carbon-ion therapy, which began in 1994. Since developing Japan’s first PET device in 1979, QST has continued to lead research in nuclear medicine physics. Over the past 15 years, the Yamaya Lab has developed 23 types of innovative PET systems.

The tour includes visits to the Heavy Ion Medical Accelerator in Chiba (HIMAC) and the PET Development Laboratory (Yamaya Lab). Bus transportation from Pacifico Yokohama will be provided, which takes approximately one hour. On the return trip, the bus will stop at Chiba Station, offering convenient access to Tokyo/Narita Airport by train for those departing from there.

Hamamatsu Photonics Tour – Central Research Laboratory

Schedule

12:50 pm – Meeting at Act City South Bus Station (Hamamatsu) – see image below
1:00 pm – Coach departs JR Hamamatsu Station
2:00 pm-4:30 pm – Guided small-group tour of the Central Research Laboratory
4:30 pm – Coach departs Hamamatsu Photonics
5:30 pm – Arrival back at JR Hamamatsu Station
(Shinkansen travel time: approx. 60–100 min between Shin-Yokohama and Hamamatsu.)

Life Photonics

Hamamatsu Photonics envisions a future where the Earth, humanity, and all living things coexist in harmony. To help realize this, our Central Research Laboratory is conducting advanced R&D under the concept of “Life Photonics,” focusing on themes such as life, vitality, and sustainable living. Our research explores the possibilities of light through both fundamental and applied science, covering areas like optical information processing, medical care, biotechnology, materials, and energy. We invite you to visit and see firsthand how we engage in this dialogue with light — the foundation of all our innovations.